Above knee amputation
If you have an above knee amputation, you may not want to sleep with a pillow under your limb. Actually, this may lead to a hip flexion contracture making it harder for you to straighten your hip. If your hip is not straight, you should be ready to face a lot of other problems as well. So, changing this habit in the beginning is a good idea.
Pillow problem
Again, it's not a good idea to sleep with a soft pillow between your limbs as this may shorten your outer thigh muscle. This may change the way your leg lays in standing position. It may be hard for you in the beginning, but will become easier with the passage of time. Soon you will get used to it.
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